hero-orange

Platform & Pipeline

Platform

Our platform consists of three fundamental elements:

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14-3-3 Encyclopedia

The 14-3-3 encyclopedia provides a systematic understanding of the 14-3-3:client interface so that we can achieve predictive, efficient structure-chemotype pairing in a modular fashion, substantially streamlining the drug discovery process. With an extensive client database of binding motifs and 14-3-3:client protein structures, we can more quickly identify the most promising candidates from our library of privileged scaffolds to begin the screening process.

Pipeline

Our pipeline currently focuses on oncology, where multiple opportunities exist to engage currently undrugged targets that are involved in oncogenic signaling, gene expression, cell cycle dysregulation, and other cancer-driving processes.

Target class
Target Activity
Stage
Target Competition
Therapeutic Area
BIC / FIC potential
Adaptor / Scaffold
Integrator / distributor of RTK & oncogenic TK signaling
Hit-to-lead
Undrugged
Oncology
FIC
Hit-to-lead
Kinase
Relay for oncogenic signaling
Hit exploration
Preclinical
Oncology
FIC
Hit exploration
Kinase
Regulator of endolysosomal processes and vesicular trafficking
Hit exploration
Clinical
Neurodegeneration
BIC
Hit exploration
TF
Regulator of cell cycle, proliferation, survival
Target validation
Clinical
Oncology
BIC
Target validation
TF
Effector of multiple oncogenic signaling pathways
Target validation
Early clinical
Oncology
BIC
Target validation