Platform & Pipeline
Platform
Our platform consists of three fundamental elements:
14-3-3 Encyclopedia
The 14-3-3 encyclopedia provides a systematic understanding of the 14-3-3:client interface so that we can achieve predictive, efficient structure-chemotype pairing in a modular fashion, substantially streamlining the drug discovery process. With an extensive client database of binding motifs and 14-3-3:client protein structures, we can more quickly identify the most promising candidates from our library of privileged scaffolds to begin the screening process.
Pipeline
Our pipeline focuses on neurodegeneration and oncology where multiple opportunities exist to engage currently undrugged targets and where a 14-3-3 molecular glue strategy is clearly differentiated from existing approaches.
*Michael J. Fox Foundation (MJFF) funded consortium; collaboration with academic experts
**Exploratory program; collaboration with academic experts
and vesicular trafficking
neurotransmitter release